Net charge, hydrophobicity and specific amino acids contribute to the activity of antimicrobial peptides.
- Author:
Jindal MH
;
Le CF
;
Mohd Yusof MY
;
Sekaran SD
- Publication Type:Review
- Keywords:
Antimicrobial peptides;
antibiotic-resistant;
net charge;
hydrophobicity
- MeSH:
Anti-Infective Agents
- From:Journal of University of Malaya Medical Centre
2014;17(1):1-7
- CountryMalaysia
- Language:English
-
Abstract:
Antimicrobial peptides (AMPs) have gained increasing attention as a potential candidate in the development
of novel antimicrobial agent. Designing AMPs with enhanced antimicrobial activity while reducing the cell
toxicity level is desired especially against the antibiotic-resistant microbes. Various approaches towards the
design of AMPs have been described and physicochemical properties of AMPs represent the primary factors
determining the antimicrobial potency of AMPs. The most common parameters include net charge and
hydrophobicity, which greatly influence the antimicrobial activity of AMPs. Moreover, certain amino acids
would have critical importance in affecting the antimicrobial activity as well as cell cytotoxicity of AMPS. In this
review, net charge, hydrophobicity, and specific amino acid residues were discussed as factors contributing
to the antimicrobial activity of AMPs.
- Full text:P020150603341535140324.pdf
