In vitro Inhibitory Potential of Selected Malaysian Plants Against Key Enzymes Involved in Hyperglycemia and Hypertension
- Author:
Loh SP
;
Hadira O
- Publication Type:Journal Article
- Keywords:
Carica papaya, Centella asiatica, Cosmos caudatus, Manihot esculenta Psophocarpus tetragonolobus, in vitro inhibitory potential
- From:
Malaysian Journal of Nutrition
2011;17(1):77-86
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: This study was conducted to determine the inhibitory potential of
selected Malaysian plants against key enzymes related to type 2 diabetes and
hypertension. Methods: The samples investigated were pucuk ubi (Manihot
esculenta), pucuk betik (Carica papaya), ulam raja (Cosmos caudatus), pegaga (Centella
asiatica) and kacang botol (Psophocarpus tetragonolobus). The inhibitory potential of
hexane and dichloromethane extracts against the enzymes were determined by
using α-amylase, α-glucosidase and angiotensin I-converting enzyme (ACE)
inhibition assay. Results: In α-amylase inhibition assay, the inhibitory potential
was highest in pucuk ubi for both hexane (59.22%) and dichloromethane extract
(54.15%). Hexane extract of pucuk ubi (95.01%) and dichloromethane extract of
kacang botol (38.94%) showed the highest inhibitory potential against α-
glucosidase,while in ACE inhibition assay, the inhibitory potential was highest
in hexane extract of pegaga (48.45%) and dichloromethane extract of pucuk betik
(59.77%). Conclusion: This study suggests a nutraceutical potential of some of
these plants for hyperglycemia and hypertension prevention associated with
type 2 diabetes.
- Full text:W020150714376869551074.pdf
