No Association of Peptide Tyrosine-Tyrosine (PYY) Gene R72T Variant with Obesity in the Kampar Health Clinic Cohort, Malaysia
- Author:
Chan PM
;
Fan SH
;
Say YH
- Publication Type:Journal Article
- Keywords:
Anthropometric measurements, Malaysia, obesity, Peptide Tyrosine-Tyrosine, single nucleotide polymorphism
- From:
Malaysian Journal of Nutrition
2011;17(2):201-212
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Peptide Tyrosine-Tyrosine (PYY) is a 36-amino acid peptide
hormone released post-prandially from the endocrine cells in the intestinal tract
to suppress pancreatic secretions and eventually reduce appetite. The R72T variant
in the PYY gene (rs1058046) has been associated with increased susceptibility to
obesity. Therefore, the objective of this study was to investigate the association
of this variant with obesity and its related anthropometric measurements among
the Kampar Health Clinic cohort, Malaysia. Methodology: A total of 197 (78
males, 119 females; 98 non-obese, 99 obese) subjects were recruited by convenience
sampling and anthropometric measurements were taken. Genotyping was
performed using StuI Polymerase Chain Reaction-Restriction Fragment Length
Polymorphism (PCR-RFLP), revealing 61 RR, 94 RT and 42 TT subjects. Results:
Most of the obese subjects had the RT genotype (50.5%), while only 18.2% were
TT. PYY R72T genotypes and alleles had no association with obesity (p=0.535;
0.074, respectively), gender (p=0.767; p=0.100, respectively) but were associated
with ethnicity (p=0.003; p=0.002, respectively). Among the 13 anthropometric
measurements taken, significant difference was only found in Waist
Circumference (WC) and Visceral Fat Level (VFL) among the alleles, suggesting
that subjects with T allele will have an increment of 1.82 cm in WC and 1.32% in
VFL. Conclusion: The R72T variant in PYY gene was not associated with obesity
and most of its related anthropometric measurements. This suggests that other
genes and/or environmental factors like dietary habits and lifestyle factors may
be the contributors of obesity.
- Full text:W020150714385112368230.pdf
