Evaluation of the Antidiabetic and Antilipaemic Activities of the Hydroalcoholic Extract of Phoenix Dactylifera Palm Leaves and Its Fractions in Alloxan-Induced Diabetic Rats
- Author:
Seyyed Ali Mard
;
Kowthar Jalalvand
;
Masoumeh Jafarinejad
;
Hoda Balochi
;
Mohammad Kazem Gharib Naseri
- Publication Type:Journal Article
- Keywords:
antidiabetics, antilipaemics, antioxidants, diabetes metabolism, plant extracts
- From:Malaysian Journal of Medical Sciences
2010;17(4):4-13
- CountryMalaysia
- Language:English
-
Abstract:
Background: The antidiabetic and antilipaemic effects of Phoenix dactylifera leaf extract
(PDE) and its fractions were investigated in various rat models.
Methods: Diabetes was induced in male Wistar rats by alloxan monohydrate. Diabetic
animals were randomly divided into 8 groups (1 diabetic control and 7 treated groups). Diabetic
control animals received saline (5 mL/kg) orally, whereas the treatment groups received different
doses of PDE (100, 200, and 400 mg/kg), PDE fractions (50, 100, and 200 mg/kg), or glibenclamide
(4 mg/kg) orally once a day for 14 days. Blood was withdrawn for glucose determination on the 1st,
6th, 10th, and 14th days. The rats were fasted overnight and then sacrificed on the 14th day; blood was
collected for biochemical evaluation, including the levels of blood glucose, plasma insulin, serum
triglyceride, and cholesterol.
Results: Subacute administration of PDE or its fractions in alloxan-induced diabetic rats
significantly reduced blood glucose (P < 0.01). Water intake, serum triglyceride, and cholesterol
also decreased in treated animals compared with the control group (P < 0.01). Plasma insulin level
increased in the treated groups relative to the control group (P < 0.01).
Conclusion: The results suggested that PDE exhibits antidiabetic and antilipaemic effects in
alloxan-induced diabetic rats.
- Full text:W020151022505764093845.pdf
