Genetic Aberrations in Childhood Acute Lymphoblastic Leukaemia: Application of High-Density Single Nucleotide Polymorphism Array
- Author:
Sarina Sulong
- Publication Type:Review
- Keywords:
B- and T-cell acute lymphoblastic leukaemia, child, cytogenetic aberrations, single nucleotide polymorphisms, oligonucleotide array sequence analysis, medical sciences
- From:Malaysian Journal of Medical Sciences
2010;17(3):5-12
- CountryMalaysia
- Language:English
-
Abstract:
Screening of the entire human genome using high-density single nucleotide polymorphism
array (SNPA) has become a powerful technique used in cancer genetics and population genetics
studies. The GeneChip® Mapping Array, introduced by Affymetrix, is one SNPA platform utilised
for genotyping studies. This GeneChip system allows researchers to gain a comprehensive view of
cancer biology on a single platform for the quantification of chromosomal amplifications, deletions,
and loss of heterozygosity or for allelic imbalance studies. Importantly, this array analysis has the
potential to reveal novel genetic findings involved in the multistep development of cancer. Given the
importance of genetic factors in leukaemogenesis and the usefulness of screening the whole genome,
SNPA analysis has been utilised in many studies to characterise genetic aberrations in childhood
acute lymphoblastic leukaemia.
- Full text:W020151022431830811913.pdf
