Effect on Antioxidant Levels in Patients of Breast Carcinoma during Neoadjuvant Chemotherapy and Mastectomy
- Author:
Gurpreet Singh
;
SK Maulik
;
Amardeep Jaiswal
;
Pratik Kumar
;
Rajinder Parshad
- Publication Type:Journal Article
- Keywords:
antineoplastic combined chemotherapy protocols, antioxidants, breast neoplasms, medical sciences
- From:Malaysian Journal of Medical Sciences
2010;17(2):24-28
- CountryMalaysia
- Language:English
-
Abstract:
Background: Breast cancer is the most common cancer in Indian women. The aim of this
study was to assess the levels of red blood cell (RBC) superoxide dismutase (r-SOD), RBC catalase
(r-CAT), RBC glutathione peroxidase (r-GPx) and the ferric reducing ability of plasma (FRAP) in
advanced breast cancer patients post mastectomy before and after chemotherapy.
Methods: Female breast cancer patients between 27 and 65 years of age who were admitted to
the Department of Surgery of the All India Institute of Medical Sciences in New Delhi were enrolled
in the study. This study included two arms: a control group of healthy age-matched females (n=20)
and patients undergoing treatment with a combination of the anticancer drugs cyclophosphamide,
doxorubicin, and 5-fluorouracil (CAF) (n=55), No treatment was given to the control group. The
CAF group received CAF treatment at weeks 0, 3, and 6, then surgery at week 9 followed by CAF
treatment at weeks 12, 15, and 18. A three-week drug-free interval was included between each cycle
of drug treatment. Blood samples were collected from control subjects and from patients in the CAF
group before administration of drugs at week zero to establish a baseline, again weeks 12 and 18, and
once more at the end of the 26-week treatment. Blood samples collected from the control subjects
and CAF patients were analysed to determine levels of the endogenous antioxidants, r-SOD, r-CAT,
r-GPx, and FRAP.
Results: Levels of r-SOD, r-CAT, r-GPx, and FRAP in CAF-treated patients at 12, 18, and 26
weeks were significantly decreased (P<0.001) in comparison to the baseline levels observed at week
zero.
Conclusion: The results from the present study show that a change in the enzyme antioxidant
systems in patients after chemotherapy and mastectomy causes an overall decrease in antioxidant
levels. Chemotherapeutic agents induce oxidative stress that damages many cellular targets.
- Full text:W020151022428195813251.pdf
