Antimicrobial susceptibility of clinical isolates of Pseudomonas aeruginosa from a Malaysian Hospital
- Author:
Siva Gowri Pathmanathan
;
Nor Azura Samat
;
Ramelah Mohamed
- Publication Type:Journal Article
- Keywords:
antibacterial agents, bacterial drug resistance, Pseudomonas aeruginosa, medical sciences
- From:Malaysian Journal of Medical Sciences
2009;16(2):27-32
- CountryMalaysia
- Language:English
-
Abstract:
Ongoing surveillance of Pseudomonas aeruginosa resistance against antimicrobial agents
is fundamental to monitor trends in susceptibility patterns and to appropriately guide clinicians in
choosing empirical or directed therapy. The in vitro activity level of eight antimicrobial drugs was
assessed against 97 clinical isolates of P. aeruginosa collected consecutively for three months in 2007
from a Malaysian hospital. Antimicrobial susceptibility was determined using the E-test method in
addition to the hospital’s routine diagnostic testing by the disk diffusion method. Respiratory and
wound swab isolates were the most frequently encountered isolates. The E-test and disk diffusion
methods showed high concordance in determining the in vitro activity of the antimicrobial agents
against the E isolates. Piperacillin-tazobactam was the most active antimicrobial agent with 91.8%
susceptibility, followed by the aminoglycosides (amikacin, 86.6% and gentamicin, 84.5%), the quinolone
(ciprofloxacin, 83.5%) and the beta-lactams (cefepime, 80.4%, ceftazidime, 80.4%, imipenem, 79.4%
and meropenem, 77.3%). Incidence of multidrug resistance was 19.6% (19 out of 97 isolates). Periodic
antibiotic resistance surveillance is fundamental to monitor changes in susceptibility patterns in a
hospital setting.
- Full text:W020151021607057163072.pdf
