The Role Of Cells, Neurotrophins, Extracellular Matrix And Cell Surface Molecules In Peripheral Nerve Regeneration
- Author:
Murali Naidu
- Publication Type:Letter
- Keywords:
cell surface molecules extracellular matrix, nerve growth factors, nerve regeneration, Schwann cells, neurosciences
- From:Malaysian Journal of Medical Sciences
2009;16(2):10-14
- CountryMalaysia
- Language:English
-
Abstract:
Wallerian degeneration is a complicated process whereby axons and myelin sheaths undergo
degeneration, and eventually are phagocytosed by macrophages and Schwann cells following nerve
damage. Schwann cells proliferate and the endoneural tubes persist. In addition, neurotrophins,
neural cell adhesion molecules, cytokines and other soluble factors are upregulated to facilitate
regeneration. The important role of cellular components, neurotrophins, and extracellular matrix
components, including cell surface molecules involved in this regenerative process, is highlighted and
discussed in this review.
- Full text:W020151021606092312316.pdf
