A Pilot Study On Percent Free Prostate Specific Antigen As An Additional Tool In Prostate Cancer Screening
- Author:
Julia Omar
;
Zarina Jaafar
;
Mohamed Rusli Abdullah
- Publication Type:Journal Article
- Keywords:
Percent free prostate specific antigen, total prostate specific antigen, prostatic cancer, medical sciences
- From:Malaysian Journal of Medical Sciences
2009;16(1):44-47
- CountryMalaysia
- Language:English
-
Abstract:
A cross sectional pilot study was carried out to look into the usefulness of percent free prostate
specific antigen (fPSA) in the diagnosis of prostatic cancer in HUSM patients. All patients who attended
surgical clinic and admitted to surgical wards with signs and symptoms of prostate problems during
the study period were taken as the study subjects. Total prostate specific antigen (tPSA) was estimated
by immunoassay technique and those values of 4 ng/mL or more were proceeded for estimation of
fPSA. Using the cut-off value of less than 25% fPSA for diagnosing patients with prostate cancer,
our study showed that majority of the prostate cancer patients have a ratio of fPSA:tPSA more than
25% and a significantly higher level of total prostate specific antigen (P<0.005) when compared with
patients with benign prostatic hyperplasia (BPH). Unexpectedly, the fPSA values were high in patients
diagnosed as prostate cancer compared to BPH. Ratio of percent fPSA to tPSA was found not to be
sensitive and specific, in diagnosing prostate cancer at the cut-off value of 25%. In conclusion, total
PSA is a more useful biochemical test for diagnosing prostate cancer in our patients.
- Full text:W020151021603891844448.pdf
