Evaluation of the histo-gastroprotective and antimicrobial activities of heliotropium indicum linn (BORAGINACEAE)
- Author:
Akinlolu Abdulazeez Adelaja
;
Ayoola M. D.
;
Otulana J. O., Akinola O. B.
;
Abimbola Olayiwola
;
A. B. Ejiwunmi
- Publication Type:Journal Article
- Keywords:
Heliotropium Indicum, Ulcerated Gastric Mucosa, Histo-Gastroprotective Effects
- From:Malaysian Journal of Medical Sciences
2008;15(3):22-30
- CountryMalaysia
- Language:English
-
Abstract:
Heliotropium indicum of the family Boraginaceae is used locally in Nigeria to treat ailments such as ulcer and fever. In this study, ulceration of the gastric mucosa in
Wistar rats was induced via the oral administration of 80mg/kg/bodyweight of Indomethacin. Histological analyses of the stomach body wall in the rats of Groups
2 and 4 (which received 100mg/kg/bodyweight of extract before oral administration of 80mg/kg/bodyweight Indomethacin and 80mg/kg/bodyweight Indomethacin only
respectively) showed erosion of the mucus-secreting cells, gastric pit, upper and middle parts of gastric glands and some of the parietal cells. Histological
observations of the stomach body wall in rats of Group 5 (which received 200mg/ kg/bodyweight of extract before oral administration of 80mg/kg/bodyweight of
Indomethacin) showed erosion of the mucus-secreting cells, gastric pit and the upper most part of the gastric gland. Histological observations of the stomach
body wall in rats of Groups 1, 6 and 3 (which received 50mg/kg/bodyweight of Ranitidine and 400mg/kg/bodyweight of extract before oral administration of 80mg/
kg/bodyweight Indomethacin; and only 80mg/kg/bodyweight of Normal Saline respectively) showed normal morphological appearance of the different components
of the mucosa layer. Thus, the aqueous extracts of the dried leaves of Heliotropium indicum have dose dependent histo-gastroprotective effects.
- Full text:W020151019516592780128.pdf
