A Comparative Study of Different Induction Techniques (Propofol-Placebo, Propofol-Ephedrine and Propofol-Placebo-Crystalloid) on Intubating Conditions after Rocuronium Administration
- Author:
Muhd Helmi Azmi
;
Karis Misiran
- Publication Type:Journal Article
- Keywords:
rocuronium, ephedrine, propofol, intubating conditions
- From:Medicine and Health
2007;2(2):103-109
- CountryMalaysia
- Language:English
-
Abstract:
This was a prospective randomized double blind controlled study to compare intubating
conditions at 60 seconds with rocuronium 0.6 mg/kg by using three different induction
techniques: propofol-placebo (PP), propofol-ephedrine (PE) and propofol-placebocrystalloid
(PC). Ninety patients were included and randomly allocated to receive one of
the three combinations. The patients were induced using fentanyl 2 μg/kg, followed by
propofol 2.5 mg/kg with normal saline as placebo (Group PP and Group PC) or ephedrine
70 μg/kg (Group PE) given over 30 seconds. Subsequently, rocuronium 0.6 mg/kg was
given over five seconds and endotracheal intubations were performed 60 seconds later.
Intubating conditions were clinically acceptable in all patients except in four patients in PP
group, who had poor intubating conditions. The proportion of excellent intubating
conditions was significantly highest in Group PE (94%) followed by Group PC (81%) and
lowest in Group PP (50%). In conclusion, induction with propofol-ephedrine and propofol-placebo-crystalloid combinations provided significantly better intubating conditions than
propofol alone, when rocuronium 0.6 mg/kg was used for intubation at 60 seconds.
- Full text:P020160928362100986623.pdf
