Concomitant t(8;21) and Trisomy 4 in a Patient with Acute Myeloid Leukemia (AML)
- Author:
Phan CL
;
Ong TC
;
Chang KM
;
Zubaidah Z
;
Puteri Jamilatul NMB
- Publication Type:Case Reports
- Keywords:
AML-FAB M2, t(8;
21), trisomy 4
- From:Medicine and Health
2010;5(1):45-48
- CountryMalaysia
- Language:English
-
Abstract:
The t(8;21)(q22;q22) is a frequently occurring aberration in acute myeloid leukemia (AML) (18-20%) and usually correlate with French-America-British (FAB) M2 subtype.
Several studies showed that patients carrying this abnormality demonstrated good response to standard chemotherapy but also have a high incidence of disease relapse. Trisomy 4 is a rare and specific chromosomal abnormality occurring in AML M2 or M4 of the FAB subtypes. We report a case of a 33-year-old female with an apparently
clinical and hematologic diagnosis of acute promyelocytic leukemia (APL) in whom cytogenetic analysis revealed an abnormal karyotype with trisomy 4, in addition to
t(8;21). Trisomy 4 and t(8;21) in a patient with AML is rare. The significance of t(8;21) with trisomy 4 in AML are unclear but patients bearing this abnormality are associated with a poor prognosis.
- Full text:P020160928395501274208.pdf
