Plasma Total Antioxidant Capacity (TAC) in Obese Malaysian Subjects
- Author:
Lim SH
;
Fan SH
;
Say YH
- Publication Type:Journal Article
- Keywords:
Plasma total antioxidant capacity, Trolox equivalent antioxidant potential, oxidative stress, obesity, Malaysia
- From:
Malaysian Journal of Nutrition
2012;18(3):345-354
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: There is a pressing need to better understand the complex biochemical pathways that lead to the pathogenesis of obesity. Increased oxidative stress and decreased antioxidant capacity have been identified to be associated with obesity. Therefore, the objectives of this study were to determine the plasma total antioxidant capacity (TAC) levels of Malaysian subjects and to
evaluate its potential association with obesity and related anthropometric measurements. Methods: Plasma TAC of 362 multi-ethnic Malaysian subjects from the Kampar Health Clinic (138 males, 224 females; 124 ethnic Malays, 152 Chinese, 86 Indians; 192 non-obese, 170 obese) was measured using Trolox equivalent antioxidant capacity (TEAC) 96-well plate assay. Results: Plasma TAC was significantly lower in obese subjects (M ± SE = 292 ± 10.4 mol/L) compared to non-obese subjects (397 ± 8.58 mol/L), whereas it was significantly higher in males and those in the 21-30 age group. Those with salty food preference
and practising a strict vegetarian diet also had significantly higher plasma TAC. However, no association was found for other dietary habits (coffee intake) and
lifestyle factors (physical activity, smoking). Plasma TAC was also significantly negatively correlated with diastolic blood pressure, waist and hip circumferences,
weight, body mass index, total body fat, % subcutaneous fat, visceral fat level, resting metabolism and % skeletal muscle. Conclusion: Plasma TAC was found
to be associated with obesity, strict vegetarian practice, salty food preference and all obesity anthropometric indicators, except systolic blood pressure and
pulse rate. Obese people have decreased plasma TAC indicating a compromised systemic antioxidant defence and increased oxidative stress.
- Full text:W020150716317092523146.pdf
