Association and Interaction Effect between VEGF Receptor- 2 (VEGFR-2) Gene Polymorphisms and Dietary Pattern on Blood Uric Acid in Malays and Indians
- Author:
Roseline Yap WK
;
Shidoji Y
;
Hon WM
;
Masaki M
- Publication Type:Journal Article
- Keywords:
Gene-diet interaction, VEGFR-2 gene polymorphisms, dietary pattern, uric acid, Malaysians
- From:
Malaysian Journal of Nutrition
2012;18(3):307-317
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Gout and hyperuricaemia attributed to genetic and lifestyle factors have been associated with several chronic diseases. This study aimed to determine
the association and interaction effects between vascular endothelial growth factor receptor-2 (VEGFR-2) gene polymorphisms (rs1870377 and rs2071559) and dietary
patterns on blood uric acid in Malay and Indian adults. Methods: Dietary intakes of 153 Malays and 177 Indians were obtained using a food frequency questionnaire for the construction of dietary patterns using factor analysis.
Genotyping of rs1870377 and rs2071559 was performed by real-time PCR using TaqMan probes. Anthropometric measurements, body mass index (BMI) and blood pressure and biomarkers, uric acid, glycated haemoglobin A1c (HbA1c),
and blood lipids were determined. Results: There were significant differences in the mean values for HbA1c (41±-12 vs 45±-8 mmol/mol, p<0.001) and blood
lipids levels (p<0.05) between Malays and Indians. Significant correlations were obtained between uric acid with selected blood lipids (p<0.05) and BMI in Malays
(r=0.362, p<0.001) and Indians (r=0.212, p<0.01). Four dietary patterns were extracted from dietary intakes of all subjects: ‘Vegetables diet’; ‘Fruits diet’ (FD);
‘Animal protein and rice diet’; and ‘Fast foods and preserved foods diet’. There were no significant associations between dietary patterns (p=0.054-0.609) and
VEGFR-2 gene polymorphisms (p=0.348-0.778) with uric acid. In Malay subjects, the interaction of rs2071559 and FD had a borderline effect (p=0.05) on blood uric
acid after adjusting for potential confounders. Conclusion: The associations and gene-diet interactions involving VEGFR-2 gene polymorphisms and FD on uric
acid provide new information on gout and hyperuricaemia risks in Malays.
- Full text:W020150714545872211380.pdf
