Trisomy X and Myelodysplastic Syndrome (MDS) with Eosinophilia
- Author:
RMT Eusni
;
CF Leong
;
S Salwati
- Publication Type:Case Reports
- Keywords:
myelodysplastic syndrome, eosinophilia, trisomy X
- From:Malaysian Journal of Medicine and Health Sciences
2012;8(2):65-67
- CountryMalaysia
- Language:English
-
Abstract:
We reported a young patient with myelodysplastic syndrome (MDS) with eosinophilia, in which her
chromosomal analysis revealed the presence of trisomy X and a marker chromosome at chromosome
11. The technique used to detect the chromosomal abnormalities is a multicoloured –fluorescent in
situ hybridization technique (M-FISH). Our observation suggested that these underlying chromosomal
abnormalities were probably responsible for her development of MDS with eosinophilia.
Myelodysplastic syndrome (MDS) is a condition whereby there is ineffective production of
haematopoietic stem cells and poor quality of cells produced. The cause can either be a primary bone
marrow problem, de novo or therapy related. Most MDS cases are secondary rather than primary. Many
chromosomal abnormalities have been found in cases of myelodysplastic syndrome. We described a
case of MDS with eosinophilia in association with presence of trisomy X and a marker chromosome in
chromosome 11.
