Elevated Expression of CD151 Gene in Estrogen Receptor and Progesterone Receptor Positive Breast Carcinoma
- Author:
Ivyna Bong PN1
;
Zubaidah Z1
;
Rohaizak M2
;
Naqiyah I2
;
Nor Aina E3
;
Noor Hisham A4
;
Sharifah NA5
- Publication Type:Journal Article
- Keywords:
qRT-PCR, expression, breast cancer, CD151
- From:Medicine and Health
2011;6(1):33-40
- CountryMalaysia
- Language:English
-
Abstract:
The tetraspanin gene, CD151 is involved in various tumour cell progression and metastasis. Its expression is increased in high grade, estrogen receptor negative and c-erbB-2 positive breast cancer. However, the biological function and expression phenotype among different tumour status, estrogen receptor (ER) status, progesterone receptor (PR) status and c-erbB-2 expression in multi-ethnic Malaysian breast cancer patients has not been well investigated. We used quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR) to measure the CD151 gene expression in 45 breast cancers. Our preliminary results revealed that CD151 expression is significantly higher in ER positive and PR positive breast cancers at 95% and 99% confidence intervals, respectively. In contrast, there is no significant correlation between CD151 expression and tumour grades or c-erbB-2 status at 95% confidence interval level. Our preliminary findings suggested that CD151 may be involved in the estrogen responsive pathways. CD151 could be a potential prognostic marker and therapeutic target in the treatment of estrogen dependent breast cancer patients.
- Full text:P020160928411431473571.pdf
