Aggressive Variant Large Granular Lymphocytic Leukaemia: A Case Report
- Author:
MN Sabariah
;
S Zainina
;
I Faridah
;
CF Leong
- Publication Type:Journal Article
- Keywords:
T-LGL, NK leukaemia, treatment of aggressive variant leukaemia
- From:Malaysian Journal of Medicine and Health Sciences
2011;7(1):57-60
- CountryMalaysia
- Language:English
-
Abstract:
Clonal disorders of LGL may either be CD3+ CD56- or CD3- CD56+ phenotype and these have
been designated as T-cell leukaemia (T-LGL) or natural killer cell (NK)-LGL leukaemia respectively.
Clonality is usually demonstrated by clonal rearrangement of T-cell receptor gene rearrangement or
identified by flowcytometry analysis. Most patients with T-LGL will have an indolent course. In this
report we described an aggressiveness of disease in a patient with clonal CD3+ LGL leukaemia whose
cells also co-expressed CD56 diagnosed by flowcytometry. The patient responded well to interrupt ALL
standard risk protocol however succumbed to her disease while waiting for upfront stem cell transplant.
This case highlights on both the classical laboratory findings of rare entity of disease as well as a review
of the literature pertaining particularly on its management.
