Antimicrobial Resistance Surveillance of Bacteria in 1999 in Korea with a Special Reference to Resistance of Enterococci to Vancomycin and Gram-Negative Bacilli to Third Generation Cephalosporin, Imipenem, and Fluoroquinolone.
10.3346/jkms.2001.16.3.262
- Author:
Kyungwon LEE
1
;
Hye Soo LEE
;
Sook Jin JANG
;
Ae Ja PARK
;
Myung Hee LEE
;
Won Keun SONG
;
Yun Sop CHONG
Author Information
1. Departments of Clinical Pathology, Yonsei University College of Medicine, Seoul, Korea. whonetkor@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Antimicrobial Drug Resistance in Korea;
Resistance Surveillance;
Vancomycin-Resistant Enterococci;
Imipenem-Resistant Pseudomonas
- MeSH:
Anti-Infective Agents, Fluoroquinolone/*pharmacology;
Antibiotics/*pharmacology;
Cephalosporins/*pharmacology;
Drug Resistance, Microbial;
Enterobacteriaceae/drug effects;
Enterococcus/*drug effects;
Gram-Negative Bacteria/*drug effects;
Human;
Imipenem/*pharmacology;
Korea;
Microbial Sensitivity Tests;
Pseudomonas aeruginosa/drug effects;
*Vancomycin Resistance
- From:Journal of Korean Medical Science
2001;16(3):262-270
- CountryRepublic of Korea
- Language:English
-
Abstract:
The trend of antimicrobial resistance of bacteria isolated from patients in 30 Korean hospitals in 1999 was analyzed with a particular attention to cefotaxime- or fluoroquinolone-resistant gram-negative bacilli, imipenem-resistant Pseudomonas aeruginosa, and vancomycin-resistant enterococci. Adequacy of susceptibility testing, and any change in the frequencies of isolated species were also analyzed. The results showed that only 20% and 30% of hospitals tested the piperacillin-tazobactam and cefoxitin susceptibility of Enterobacteriaceae, respectively, only 24% of hospitals the piperacillin-tazobactam susceptibility of P. aeruginosa, and 17% of hospitals the fusidic acid susceptibility of staphylococci. Among the isolates 26.3% were glucose-nonfermenting gram-negative bacilli, and 34.7% of Enterococcus were Enterococcus faecium. Slight decline of cefotaxime-resistance rate to 20% was noted in Klebsiella pneumoniae, while fluoroquinolone-resistantce rate was 68% in Acinetobacter baumannii. The ceftazidime- and imipenem-resistance rates were 17% and 18%, respectively in P. aeruginosa. The vancomycin-resistance rate of E. faecium rose significantly to 15.1%, but the rates varied significantly depending on hospitals suggesting presence of different degree of selective pressure or nosocomial spread. In conclusion, the prevalence of imipenem-resistant P. aeruginosa and the increase of vancomycin-resistant E. faecium were the particularly worrisome phenomena observed in this study.
