Development of semi-empirical model for radiochemical reactions.
10.3346/jkms.2001.16.3.283
- Author:
Rena J LEE
1
;
Hyun Suk SUH
Author Information
1. Department of Radiation Oncology, Ewha Womans University Mokdong Hospital, Seoul, Korea. renalee@hotmail.com
- Publication Type:Original Article
- Keywords:
Free Radicals;
Cell Survival;
Models Theoretical
- MeSH:
Cell Survival;
DNA/*chemistry;
Free Radicals/*chemistry;
Hydroxyl Radical/chemistry;
*Models, Molecular
- From:Journal of Korean Medical Science
2001;16(3):283-289
- CountryRepublic of Korea
- Language:English
-
Abstract:
A mathematical model, which represents the radio-chemical reactions in water, was developed to study the effect of the radio-chemical products on cell kiling. The five differential equations were solved using dose rate equation and cell survival as a function of dose was computed. The known chemical rate constants were taken from the literature and unknown constants were determined by curve fitting to an experimental data. Sensitivity studies were performed by varying the rate constants and showed that the yield of H-radical had little effect whereas the change in concentration of OH-radical and direct interaction resulted in significant change on cell survival. The sensitivity studies showed good agreement with the observed effects. In conclusion, we developed a mathematical model that could be used as a means for the estimation of radiation damage.
