Viable myocardium in reperfused acute myocardial infarction: rest and stress first-pass mr imaging.
10.3346/jkms.2001.16.3.294
- Author:
Kyung Il CHUNG
1
;
Tae Sub CHUNG
;
Richard D WHITE
;
Hanns J WEINMANN
;
Tae Hwan LIM
;
Byung Il CHOI
;
Jung Ho SUH
Author Information
1. Department of Diagnostic Radiology, Ajou University Hospital, Suwon, Korea. chki@madang.ajou.ac.kr
- Publication Type:Original Article
- Keywords:
Perfusion Heart;
Magnetic Resonance Spectroscopy;
Myocardial Infarction;
Myocardium;
Myocardial Reperfusion;
Image Enhancement
- MeSH:
Animal;
Cats;
Heart/*radiography;
Hyperemia/*radiography;
Magnetic Resonance Imaging;
Myocardial Infarction/*radiography;
Myocardial Reperfusion Injury/*radiography;
Stress
- From:Journal of Korean Medical Science
2001;16(3):294-302
- CountryRepublic of Korea
- Language:English
-
Abstract:
Feasibility of identifying viable myocardium in rest and stress magnetic resonance imaging (MRI) was evaluated using 3 hr occlusion and 30 min reperfusion model of left anterior descending (LAD) coronary artery in 12 felines. At rest MRI, viable myocardium confirmed by 2,3,5-triphenyl tetrazolium chloride (TTC)- staining showed rapid signal intensity (SI) rise followed by gradual decline not significantly different from normal myocardium that the two hyperperfused regions were distinguishable only from the hypoperfused nonviable myocardium. At stress MRI, hyperemia induced perfusion change was most pronounced in normal myocardium with earlier and greater peak enhancement followed by brisk 'washout' phase while minimally augmented enhancement in viable myocardium was still in 'washin' phase. From these findings, it was concluded that viable myocardium is identified in rest and stress MRI as redistributing hypo- perfusion compared to persistent hyper-perfusion of the normal myocardium and the persistent hypo-perfusion of the nonviable myocardium.
