Clinical Trial with Tamsulosin and Doxazosin for the Treatment of Premature Ejaculation in Patients with Co-morbid LUTS: a Comparative Study.
- Author:
Young Kwon HONG
1
;
Dong Soo PARK
;
Jae Yup HONG
;
Jae Seung CHUNG
;
Seong Jin JEONG
;
Sung Kyu HONG
;
Sang Eun LEE
;
Seok Heun JANG
;
Jae Il KIM
Author Information
1. Department of Urology, Bundang CHA Hospital, College of Medicine, Pochon CHA University, Kyunggi, Korea. dsparkmd@cha.ac.kr
- Publication Type:Clinical Trial ; Comparative Study ; Original Article ; Randomized Controlled Trial
- Keywords:
Ejaculation;
Tamsulosin;
Doxazosin
- MeSH:
Doxazosin;
Ejaculation;
Humans;
Lower Urinary Tract Symptoms;
Male;
Mass Screening;
Premature Ejaculation;
Surveys and Questionnaires;
Reproductive Health;
Sulfonamides
- From:Korean Journal of Andrology
2009;27(1):49-54
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: We wanted to evaluate the therapeutic potential of a low dose of tamsulosin, as compared with doxazosin, for the treatment of premature ejaculation in men with lower urinary tract symptoms (LUTS). MATERIALS AND METHODS: Ninety-six patients (mean age: 55 years) who had LUTS with premature ejaculation were randomly assigned to receive 0.2 mg of tamsulosin and 4 mg of doxazosin daily for a period of 3 months. Patients were evaluated by taking the medical history, the International Prostatic Symptom Score (IPSS) and the Male Sexual Health Questionnaire (MSHQ) for ejaculatory function. The intravaginal ejaculatory latency time (IELT) measured by the patient's estimation and the sexual satisfaction ratio of both the partner and patient were investigated twice during the screening period and after treatment. At 3 months later, we assessed the differences in the IPSS score, the MSHQ score, the IELT and the sexual satisfaction ratio between the two groups. RESULTS: The two alpha 1-adrenoceptor antagonists had significant effects on the IPSS (p<0.05). However, we failed to find a statistically significant difference for each medication and the total MSHQ ejaculatory function score after medication in each group. The IELT was prolonged from 2.7+/-1.6 to 3.5+/-1.5 minutes and from 2.9+/-1.8 to 3.5+/-1.9 minutes in the tamsulosin and doxazosin groups, respectively. However, there was also no statistically significant difference of the IELT and the sexual satisfaction ratio in either group. CONCLUSIONS: For patients with premature ejaculation and LUTS, 0.2mg of tamsulosin improved the voiding symptoms, as assessed with the IPSS, as 4mg of doxazosin did, but neither medication seemed to be effective for the treatment of premature ejaculation.
