Relationship between Therapeutic Response and Plasma HVA/5-HIAA Ratio in Newly Admitted Schizophrenia.
- Author:
Hoe Duck KOO
1
;
Hae Sook SUH
;
Kwang Hyeon KIM
;
Chul Eung KIM
Author Information
1. Yong-In Mental Hospital, Korea.
- Publication Type:Original Article
- Keywords:
Schizophernia;
Responder;
Non-responder;
Plasma HVA/5-HIAA ratio
- MeSH:
Dopamine;
Haloperidol;
Humans;
Hydroxyindoleacetic Acid;
Plasma*;
Prospective Studies;
Schizophrenia*;
Serotonin
- From:Korean Journal of Psychopharmacology
1997;8(1):101-106
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Twenty newly admitted acute schizophrenic patients were treated with haloperidol for 6 weeks. HVA and 5-HIAA were sampled at baseline, 3days after initial neuroleptic dose, and after 1, 2, 3, 4, 6 weeks of treatment. Nine patients were classified as responders in this prospective haloperidol treatment trial. They had a score of change in the BPRS total scores of 25% or greater. Eleven patients were classified as nonresponders, based on a score of changes in the BPRS total scores of less than 25%. 1) There was no significant difference in plasma HVA/5-HIAA ratio between responder and non-responder before and after haloperidol treatment. 2) There was no significant correlations between plasma HVA/5-HIAA ratio and BPRS total scores. This study could not support the hypothesis that neuroleptic treatment would be effective by changing dopamine and serotonin function and/or by altering their interaction.
