Effect of 5-HT2c Receptor Modulation on the m-Chlorophenlpiperazine-Induced Hypoactivity.
- Author:
Woo Seong JANG
1
;
Won Tan BYUN
;
Young In CHUNG
;
Won Suk LEE
Author Information
1. Department of Psychiatry, Yang San Hospital, Yang San, Kyoung Nam, Korea.
- Publication Type:Original Article
- Keywords:
5-HT(2c)receptor;
m-Chlorophenylpiperazine;
Behavioral responses
- MeSH:
Animals;
Down-Regulation;
Imipramine;
Ketanserin;
Mianserin;
Rats;
Receptor, Serotonin, 5-HT2C*;
Serotonin 5-HT2 Receptor Antagonists;
Trazodone;
Walking
- From:Korean Journal of Psychopharmacology
1997;8(1):107-112
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
It was aimed to investigate the effect of 5-HT2C receptor modulation on the rat behavioral responses induced by 1-(m-chlorophenyl) piperazine(mCPP), a major metabolite of trazodone. The animal activities(ambulation, stereotypy and total activity) were measured for 3 hours following mCPP administration, using an animal activity meter which accumulates the frequency of light beam interruption. mCPP(1-10 mg / kg, i.p.) induced dose-dependent decreases in ambulation and stereotypy, consequently leading to hypoactivity. The hypoactivity induced by mCPP(1mg / kg, i.p.) was significantly inhibited by pretreatment with mianserin(1mg / kg, i.p.), an antagonist with high affinity for 5-HT2C receptor, whereas pretreatment with 5-HT2 antagonists, ketanserin and ritanserin(1mg / kg, i.p., respectively) was without effect. Furthermore, long-term pretreatment with imipramine(10mg / kg, i.p., b.i.d. for 2 weeks) markedly attenuated the mCPP-induced hypoactivity. Mianserin and imipramine in the absence of mCPP did not increase the animal activity. Taken together, these results indicate that the mCPP-induced hypoactivity is mediated by 5-HT2C receptor, and that selective 5-HT2C antagonists and down regulation of 5-HT2C receptor might be useful for inhibiting the mCPP-induced hypoactivity.
