Effects of Methysergide on Serum Growth Hormone Response after Electroconvulsive Therapy.
- Author:
Won Myong BAHK
1
;
Jun Hyun YOON
;
Kwang Soo KIM
;
Chung Tai LEE
;
Tae Yul LEW
Author Information
1. Department of Neuropsychiatry, St. Mary' Hospital, Catholic University Medical College, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Electroconvulsive therapy;
Growth hormone;
Methysergide
- MeSH:
Electroconvulsive Therapy*;
Electrodes;
Growth Hormone*;
Humans;
Methysergide*;
Radioimmunoassay
- From:Korean Journal of Psychopharmacology
1997;8(1):113-117
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The purpose of this study was to investigate the effects of methysergide(serotonin receptor antagonist) on serum growth hormone response after electroconvulsive therapy(ECT). METHODS: We studied the changes of the serum growth hormone levels of the day before ECT(No ECT), ECT without methysergide pretreatment(ECT alone), and ECT with methysergide pretreatment(M+ECT) by radioimmunoassay method in 14 psychiatric patients. ECT was induced by the application of 110 volts for a period 0.3-1.0 second, using bitemporal electrodes. RESULTS: 1) Serum growth hormone levels at 15, 30, and 60 minutes after ECT were significantly increased in the ECT alone group than in the No ECT group(p<0.05). 2) Serum growth hormone levels at 15, 30, and 60 minites after ECT were significantly decreased in the M+ECT group than in the ECT alone group(p<0.05). CONCLUSION: These results suggest that the response of growth hormone after ECT seems to be mediated by the activation of serotonergic system.
