Identification of the P Genotypes of rotavirus in children with acute diarrhea in Pekanbaru, Indonesia
- Author:
Fauzia Andrini Djojosugito
;
Maya Savira
;
Dewi Anggraini
;
Andani Eka Putra
- Publication Type:Journal Article
- Keywords:
diarrhea;
rotavirus;
P genotypes;
children
- MeSH:
Diarrhea;
Rotavirus
- From:Malaysian Journal of Microbiology
2017;13(1):xx-xx
- CountryMalaysia
- Language:English
-
Abstract:
Aims: Acute diarrhea is still one of the major causes of death in children under five years old worldwide, including
Indonesia. Data from the World Health Organization (WHO) Southeast Asia Region shows that acute diarrhea has
caused approximately 10-11% of death in children under five years old and rotavirus (RV) is one of the major causes.
This study is conducted to identify the profile and P genotypes of RV among children with acute diarrhea in Pekanbaru.
Methodology and results: Descriptive cross sectional study was conducted in children within the range of age 0-60
months with acute diarrhea who admitted to the government clinics and General Hospital of Riau Province from January
to July 2015. Immunochrommatography and RT-PCR were used to identify the P genotype of RV from the stool
specimens. The profile of patients was investigated including age, sex, hydration and nutritional status, also the
exclusive breastfeeding. There were 71 children who suffered from acute diarrhea and 62.0% of stools specimens were
positive by RT-PCR for RV infection. The highest rate was in the age group of 6-35 month (70.5%). Most of the patients
were female (54.5%), the history of exclusive breastfeeding (54.5%), with moderate dehydration (54.5%) and good
nutritional status (97.7%). The RV genotyping results showed the highest proportion was found in the P4 genotype
(31.8%), followed by the P8 and P6 genotype, respectively 18.2% and 13.6%, P9 (11.4%), P10 (9.1%), P11 (2.3%) and
indeterminate genotype (13.6%).
Conclusion, significance and impact of study: Rotavirus was found to be a considerable role as the etiology of
diarrhea in children under five years in Pekanbaru and rotavirus P4 genotype was predominant. The result of this study
is important for designing antigen-antibody diagnostics against RV.
- Full text:P020170308385022268434.pdf
