Influence of Soluble Fillers in Improving Porosity of Handmade Antibiotic-Impregnated Polymethyl Methacrylate (PMMA) Beads: An in-vitro Study
- Author:
Rasyid HN
;
Soegijoko S
- Publication Type:Journal Article
- Keywords:
Drug delivery system;
gentamicin;
PMMA;
soluble fillers;
glycine;
sodium chloride
- MeSH:
Polymethyl Methacrylate
- From:Malaysian Orthopaedic Journal
2016;10(2):6-10
- CountryMalaysia
- Language:English
-
Abstract:
There have been many investigations on non-biodegradable
materials acting as an antibiotic carrier for local drug
delivery systems based on polymethyl methacrylate
(PMMA) beads. However, the material is non-degradable
and non-porous so that less than 5% of the encapsulated drug
is released. In order to obtain better release of the antibiotics,
greater porosity of the beads would be required. Adding
fillers could increase the bead’s porosity, thus improving the
antibiotic release from the beads. The purpose of the study is
to optimize release kinetics of gentamicin from handmade
beads by adding fillers such as glycine and sodium chloride
in different concentrations. Terms of percolation theory will
qualitatively be applied in interpreting the final results.
Model beads were made by blending the antibiotics
(gentamicin) with powdered PMMA, prepared with the
inclusion of glycine and different concentration of sodium
chloride in 100% monomer. To determine the gentamicin
release, beads were placed in phosphate buffered saline
(PBS) and aliquots were taken at designated times to
measure the gentamicin concentration. Addition of glycine
yielded 16 % release of the total amount of gentamicin
incorporated in 24 hours. Subsequent addition of sodium
chloride resulted in an increased gentamicin release, with
little or no difference in gentamicin release once 16 g or
more sodium chloride was added (gentamicin release 100%
of the amount incorporated). In conclusion, addition of
glycine and sodium chloride resulted in an increased release
of gentamicin; however, the combination without sodium
chloride seemed to have an inhibitory effect on the
gentamicin release.
- Full text:P020160923494346133699.pdf
