Antimicrobial activities of stembark and wood extracts from Nauclea subdita against pathogenic microorganisms
- Author:
Fatin Ruzanna Jamaluddin
;
Lee Seng Hua
;
Zaidon Ashaari
;
Razak Wahab
;
Jamaluddin Mohd Daud
- Publication Type:Journal Article
- Keywords:
Nauclea subdita;
antimicrobial activity;
minimal inhibitory concentration;
minimal bactericidal concentration
- MeSH:
Anti-Infective Agents
- From:Malaysian Journal of Microbiology
2015;11(4):365-372
- CountryMalaysia
- Language:English
-
Abstract:
Aims: The aim of the study was to investigate the antimicrobial activity of Nauclea subdita (Korth) Steud against six
pathogenic microorganisms.
Methodology and results: Young and matured trees of N. subdita were cut and separated into bark and wood parts,
respectively, prior to extraction process. Phytochemical screening tests, antimicrobial activity, minimal inhibitory
concentration (MIC) and minimal bactericidal concentration (MBC) values were determined. Preliminary screening for
phytochemical components showed that both young and matured tree had similar constituents. Extracts from matured
tree showed more potency in terms of the zones of inhibition sizes than the young tree. Extract of N. subdita was more
potent to both marine bacteria, Vibrio parahaemoliticus and V. alginolyticus, while Candida albican and Aspergillus niger
were resistant to it. The sensitivity test showed that 500 µg/mL is the optimum concentration for extract of bottom
sapwood of mature tree to act as bactericidal.
Conclusion, significance and impact study: The results from this study suggest that N. subdita bark and wood
extracts may serve as potential source of antimicrobial agents for future development in medicine applications.
- Full text:P020151209393725161372.pdf
