Extensive myelofibrosis responsive to treatment for acute erythroblastic leukaemia.
- Author:
S-Abdul-Wahid Fadilah
;
Raja-Sabudin Raja-Zahratul-Azma
;
Chooi-Fun Leong
- Publication Type:Journal Article
- MeSH:
Myelofibrosis;
Acute;
Leukemia, Myelocytic, Acute;
therapeutic aspects;
prognostic
- From:The Malaysian journal of pathology
2006;28(1):55-8
- CountryMalaysia
- Language:Malay
-
Abstract:
Intense myelofibrosis is rarely associated with de novo acute myeloid leukaemia (AML) except in acute megakaryoblastic leukaemia (AML-M7) where there is diffuse marrow fibrosis as a consequence of proliferation of neoplastic myeloid cells. AML associated with significant myelofibrosis developing both de novo or secondary to primary (idiopathic) myelofibrosis is characterised by a fulminant course and extremely poor prognosis, primarily due to treatment-resistant disease. The prognostic value of degree of marrow fibrosis in de novo AML has been poorly investigated. We describe a case of extensive myelofibrosis associated with acute erythroblastic leukaemia (AML-M6) that responded to induction therapy of the leukaemia.
