Prevalence of Vitamin D Deficiency in Patients Presenting with an Orthopaedic Trauma at a Tertiary Centre in South India - Implications and Protocols for Replacement Therapy
- Author:
Cherian VM
;
Gouse M
;
Albert S
;
Jayasankar V
- Publication Type:Journal Article
- MeSH:
Vitamin D Deficiency
- From:Malaysian Orthopaedic Journal
2015;9(2):21-25
- CountryMalaysia
- Language:English
-
Abstract:
Vitamin D has been the focus of much scientific literature in
recent years owing to various studies showing its association
with a wide variety of pathological conditions 1,2
. Sun
exposure, diet and fortified supplementation account for a
bulk of Vitamin D intake in humans. Activation of vitamin D
is sequential and requires sun exposure for conversion of 7-
dehydrocholesterol to Vitamin D3. Further metabolism in
the liver converts Vitamin D3 to 25 –hydroxyvitamin D3.
Conversion to its active form 1,25 dihydroxyvitamin D3
(Calcitriol) occurs in the kidneys 2
. The importance of
Vitamin D in calcium metabolism and bone health is well
known and documented. Controversies exist regarding the
true prevalence of hypovitaminosis, however in developing
countries the prevalence of vitamin D deficiency in all age
groups is probably higher 3
. Adding to this the burden and
morbidity of skeletal trauma, persistent deficiency may have
a deleterious effect in the injured 4, 5
. Vitamin D, with its
positive effect on bone health does play a role in the biology
of fracture repair and remodelling 6
. The role of Vitamin D
replacement as sole biological effectors in fracture repair
may be difficult to quantify and confounded by other
variables at play in bone healing. Studies looking at vitamin
D levels in orthopaedic patients have also shown significant
levels of deficiency and have put forward recommendations
for evaluation and supplementation
- Full text:P020151027551784558541.pdf
