The effect of water extracts of Euphorbia hirta on cartilage degeneration in arthritic rats.
- Author:
Kah Heng Lee
;
Yu Sui Chen
;
John Paul Judson
;
Srikumar Chakravarthi
;
Yen Mi Sim
;
Hui Meng Er
- Publication Type:Journal Article
- MeSH:
Upper case ee;
Rattus norvegicus;
Euphorbia;
Water;
Degeneration, NOS
- From:The Malaysian journal of pathology
2008;30(2):95-102
- CountryMalaysia
- Language:Malay
-
Abstract:
The effect of water extracts of Euphorbia hirta on the histological features and expressions of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) in the rat articular cartilage was investigated. Arthritis was induced in rats using Freund's Complete Adjuvant containing heat-killed M. tuberculosis, and treated with water extracts of E. hirta. Paraffin tissue sections of the arthritic joints were evaluated. The extent of cartilage degeneration was found to be greatest in rats treated with the highest dosage of E. hirta, followed by rats in the untreated group. Rats treated with the intermediary and low dosages of Euphorbia hirta showed improved histology. MMP-13 levels were found to be decreased with decreasing dosages of E. hirta. TIMP-1 levels were found to increase with decreasing dosages of E. hirta. MMP-3 levels fluctuated without any appreciable pattern. Low dosages of E. hirta seem to be beneficial in reducing cartilage degeneration in cases of arthritis.
- Full text:W020151202518718754282.pdf
