Lack of Rb2/p130 genetic alteration in Malaysian nasopharyngeal carcinoma.
- Author:
Susan Ling Ling Hoe
;
Ee Soo Lee
;
Alan Soo Beng Khoo
;
Suat-Cheng Peh
- Publication Type:Journal Article
- MeSH:
Genetic;
MALAYSIAN;
Genes;
Carcinoma;
Malignant Neoplasms
- From:The Malaysian journal of pathology
2009;31(1):53-6
- CountryMalaysia
- Language:Malay
-
Abstract:
The retinoblastoma-related gene Rb2/p130 has been reported to be mutated in several malignancies such as lung cancer and Burkitt's lymphoma. Nasopharyngeal carcinoma (NPC) is a common cancer in Malaysia especially amongst the ethnic Chinese. We screened for Rb2/p130 gene (exons 19 to 21) mutations in 53 archival NPC samples via PCR-SSCP-direct sequencing approach. Only one sample had a base change which involved a serine to glycine substitution at codon 995 (S995G). We conclude that Rb2/p130 genetic alterations are infrequent in NPC and may not be essential for the pathogenesis of the disease.
- Full text:W020151202532177031165.pdf
