Three Cases of Letterer - Siwe Disease.
- Author:
Hyung Gi CHA
;
Doo Chan MOON
;
Kyung Soll KWON
;
Tae Ahn CHUNG
- Publication Type:Case Report
- Keywords:
Langerhans cell histiocytosis;
Langerhans granules;
Letterer-Siwe disease
- MeSH:
Eosinophilic Granuloma;
Histiocytosis, Langerhans-Cell;
Humans;
Liver;
Lymph Nodes;
Skin;
Spleen
- From:Korean Journal of Dermatology
1994;32(1):186-192
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Letterer-Siwe disease is one of Langerhans cell histiocytosis, with Hand-Schuller-Christian disease and eosinophilic granuloma, characterized by proliferation of Langevha is cell. The clinical course of Letterer-Siwe disease is acute fulmunant of casionally fatal, involving skin and many other internal organs, such as the lymph node, liver, spleen, ung and bone. We present 3 cases of Letterer-Siwe disease with characteristic cutaneous findings and revealed Langerhans granules by imrriunohistochemical stain and electronmicrc scopic examination. All patients died in spite of combined chernotherapy.
