Clozapine Re-Challenge With Lithium Supplementation Following Clozapine-Induced Neutropenia
- Author:
Ahmad Nabil Md Rosli
;
Rakesh Subbiah
;
T Maniam
- Publication Type:Case Reports
- Keywords:
Clozapine;
Clozapine Re-challenge;
Lithium;
Neutropenia
- MeSH:
Clozapine;
Lithium;
Neutropenia;
Schizophrenia
- From:ASEAN Journal of Psychiatry
2014;15(1):90-92
- CountryMalaysia
- Language:English
-
Abstract:
Objectives: This paper aims to report on a case in which re-challenging with clozapine in combination with lithium in a patient who developed neutropenia was carried out. Methods: The patient was treated with clozapine for treatmentresistant schizophrenia. After five weeks he showed much improvement but developed neutropenia. Withdrawal of clozapine brought on a relapse of
psychotic symptoms. Subsequently, clozapine was reintroduced along with Lithium. The neutrophil count was monitored closely. Results: The neutrophil and white blood cell count were noted to return to normal upon re-challenging, and the patient’s clinical condition also improved. Conclusion: Simultaneous administration of lithium and clozapine to patients experiencing neutropenia on clozapine is a possible strategy. However, very close monitoring of the white count is needed.
- Full text:P020140821596248596940.pdf
