Aplasia cutis congenita secondary to maternal exposureto carbimazole during pregnancy. A case report
- Author:
Tey KE
;
Chong YT
;
Choon SE
- Publication Type:Case Reports
- Keywords:
Aplasia cutis congenita, carbimazole, pregnancy
- From:Malaysian Journal of Dermatology
2009;23(-):24-26
- CountryMalaysia
- Language:English
-
Abstract:
Aplasia cutis congenita (ACC) is a rare anomaly
presenting with absence of skin. It was first
reported by Cordon in 1767. About 70% of cases
manifests as a solitary defect on the scalp, but
sometimes it may occur as multiple lesions. The
lesions are typically well demarcated, non-inflamed,
and they range in size from 0.5cm to 10cm. ACC
may be circular, oval, linear, or stellate in
configuration. At birth, lesions may appear as scars
or ulcers1. They may appear as parchment-like scars
with alopecia.
Most lesions occur on the scalp vertex just lateral to
the midline, but defects may also occur on the face,
the trunk, or the limbs, sometimes symmetrically.
The depth may involve only the epidermis and the
upper dermis, resulting in minimal alopecic
scarring, or the defect may extend to the deep
dermis, the subcutaneous tissue, or rarely the
periosteum, the skull, and the dura.
ACC is most often a benign isolated defect, but it
can be associated with other physical anomalies or
malformation syndromes. Frieden classified them
into 9 groups based on the number and presence or
absence of other anomalies1. Nearly 86 percent
belong to the first group with a solitary lesion. We
report a case of Aplasia Cutis Congenita secondary
to maternal exposure to carbimazole during
pregnancy.
