Treatment of Erythema Nodosum Leprosum (ENL) with high-dose Clofazimine in patients with Lepromatous Leprosy
- Author:
Ong ML
;
Rohna R
- Publication Type:Case Reports
- Keywords:
erythema nodosum leprosum, multibacillary leprosy, clofazimine, steroid-dependent
- From:Malaysian Journal of Dermatology
2010;25(-):7-9
- CountryMalaysia
- Language:English
-
Abstract:
ENL is a type ll leprosy reaction and occurs in
people with borderline lepromatous and
lepromatous leprosy, usually as a complication
following treatment. The treatment of choice for
ENL is prednisolone in view of its’ ready
availability and affordability1. Howeve r,
glucocorticoid therapy, even in low doses, can
produce substantial toxicity. The risk is clearly
greater as the dose increases. However, in cases
where there are steroid-induced complications,
high-dosed clofazimine may be used to reduce or
withdraw corticosteroids in steroid-dependant
cases2,3. We described 2 steroid-dependent ENL
patients with steroid-induced complications who
are successfully managed with the addition of highdosed
clofazimine and the resultant weaning down
of systemic glucocorticoids.
