The Association Between Unexplained Second-Trimester Maternal Serum Alpha-Fetoprotein or Human Chorionic Gonadotropin Elevations and Perinatal Complications.
- Author:
Ja Young JEONG
1
;
Jae Seong PARK
;
Sung Su KANG
;
Kyeong Min JEONG
;
An Teak KIM
;
Yong Ho MOON
;
Ki Sung CHUNG
Author Information
1. Department of Obstetrics and Gynecology, Masan Samsung General Hospital, Korea.
- Publication Type:Original Article
- Keywords:
Unexplained elevation;
Maternal serum alpha-fetoprotein;
Human chorionic gonadotropin;
Pregnancy induced hypertension;
preeclampsia
- MeSH:
alpha-Fetoproteins*;
Chorion;
Chorionic Gonadotropin*;
Female;
Humans*;
Hydatidiform Mole;
Hypertension, Pregnancy-Induced;
Incidence;
Pre-Eclampsia;
Pregnancy;
Pregnancy, Multiple
- From:Korean Journal of Obstetrics and Gynecology
1997;40(9):1858-1862
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Our purpose was to study the correlation between elevated maternal serum alpha-fetoprotein(MSAFP) or human chorionic gonadotropin(HCG) levels and pregnancy-induced hypertension (PIH), preeclampsia, preterm delivery. MSAFP and HCG levels were measured in stored second-trimester(14~22 weeks) serum obtained from 510 women. The criteria for patients with unexplained MSAFP elevations were a MSAFP level 2.5 or greater multiples of the median(MoM) and HCG elevations were a HCG level 2.0 or greater multiples of the median(MoM) excluding multiple pregnancy, fetal malformation or death on ultra-sonography and molar pregnancy. In contrast, patients with MSAFP levels 0.5 to < 2.5 MoM, HCG levels < 2.0 MoM were served as controls. Women with elevated HCG levels had more significant association with PIH than control group(22.2 % versus 3.4 % ; p < .005). Elevated MSAFP was significantly associated with preeclampsia(7.7 % versus 1.1 % ; p < .05). But no significant differences were observed in the incidence of preterm delivery. We suggested elevated second-trimester MSAFP or HCG levels appear to be correlated with high risk for PIH and preeclampsia. So, These patients require careful monitoring with adequate obstetric managements.
