A Case of Paradoxical Reaction Development during Antituberculosis Therapy.
10.4166/kjg.2015.65.5.306
- Author:
Young Bum CHO
1
;
Min Su CHU
;
Han Seung RYU
;
Suck Chei CHOI
;
Geom Seog SEO
Author Information
1. Department of Internal Medicine, Digestive Disease Research Institute, Wonkwang University School of Medicine, Iksan, Korea. medsgs@wonkwang.ac.kr
- Publication Type:Case Reports ; English Abstract
- Keywords:
Paradoxical reaction;
Peritonitis, tuberculous;
Tuberculosis, pulmonary;
Corticosteroid
- MeSH:
Abscess;
Adrenal Cortex Hormones/therapeutic use;
Antitubercular Agents/*therapeutic use;
Drainage;
Female;
Humans;
Mesenteric Lymphadenitis/etiology;
Tomography, X-Ray Computed;
Tuberculosis/*drug therapy/pathology;
Tuberculosis, Pulmonary/diagnosis/pathology;
Young Adult
- From:The Korean Journal of Gastroenterology
2015;65(5):306-311
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Paradoxical reaction during antituberculosis therapy is defined as aggravation of preexisting tuberculous lesions or the development of new lesions. A 24-year-old female college student diagnosed with abdominal and pulmonary tuberculosis presented with fever and abdominal pain after having been treated with antituberculosis agents for 4 months. Tuberculous mesenteric lymphadenitis was suspected on abdominal CT scan and enlarged necrotic abscess was also present. These findings were considered to be due to paradoxical reaction rather than treatment failure during antituberculosis treatment. Although laparoscopic bowel adhesiolysis and abscess drainage were performed, high fever and severe abdominal pain did not improve. However, the patient eventually made a completely recovery after corticosteroid therapy combined with antituberculosis agents. Herein, we report a case of paradoxical reaction which developed in a patient with abdominal and pulmonary tuberculosis during antituberculosis therapy.
