Relationship between serum high-sensitivity C-reactive protein levels and cognitive function in patients with Parkinson’s disease
- Author:
Seong-Min Choi
;
Byeong C Kim
;
Kyung Wook Kang
;
Kang- Ho Choi
;
Tai-Seung Nam
;
Joon-Tae Kim
;
Seung-Han Lee
;
Man-Seok Park
;
Myeong-Kyu Kim
;
Ki-Hyun Cho
- Publication Type:Journal Article
- Keywords:
Parkinson disease (PD)
- MeSH:
Dementia
- From:Neurology Asia
2016;21(4):349-356
- CountryMalaysia
- Language:English
-
Abstract:
Inflammation might be associated with cognitive impairment and be involved in the pathogenesis of
Parkinson’s disease (PD). High-sensitivity C-reactive protein (hs-CRP) is a sensitive biomarker of
systemic inflammation. This study aimed to investigate whether serum concentrations of hs-CRP are
related to cognitive function in patients with PD. Patients with PD (n = 113, Hoehn and Yahr [H-Y] stage
1-4) underwent evaluation of serum hs-CRP and comprehensive neuropsychological tests that covered
the cognitive domains of attention, language, visuospatial function, memory, and executive functions.
We categorized subjects with PD as having normal cognition (n=48), mild cognitive impairment (MCI)
(n=41), or dementia (n=24). Patients with dementia had a higher hs-CRP level than patients with MCI
or normal cognition (2.76 ± 2.53 vs. 1.27 ± 1.99 vs. 0.73 ± 0.88 mg/L, P=0.001). Serum hs-CRP
levels were inversely associated with the Mini-Mental State Examination scores and performance on
neuropsychological tests of language, visuospatial function, visual memory, and executive function.
After controlling for age, sex, symptom duration, education, H-Y stage, and Unified Parkinson’s Disease
Rating Scale motor score, multiple regression analyses indicated statistically significant associations
between hs-CRP levels and performance on neuropsychological tests of visuospatial function, visual
memory, and executive function. This study suggests a possible relationship between serum hs-CRP
levels and cognitive function in patients with PD, with higher levels of hs-CRP being associated with
poor performance on tests of visuospatial function, visual memory, and executive function.
- Full text:P020170206413005078183.pdf
