Medium-chain triglyceride ketogenic diet for drugresistant epilepsy in Taiwan: A prospective study in a single center
- Author:
Yi-Shan Wang
;
Meng-Ying Hsieh
;
Po-Cheng Hung
;
Min-Liang Chou
;
Jainn-Jim Lin
;
I-Jun Chou
;
Wan-Ling Huang
;
Huei-Shyong Wang
;
Kuang-Lin Lin
- Publication Type:Journal Article
- MeSH:
Epilepsy
- From:Neurology Asia
2016;21(4):341-347
- CountryMalaysia
- Language:English
-
Abstract:
Objective: This study aimed to determine the efficacy of a medium-chain triglyceride ketogenic diet
on patients with drug-resistant epilepsy over a period of 1 year and 8 months. Methods: Patients
with refractory epilepsy on a medium-chain triglyceride ketogenic diet were prospectively enrolled.
Their clinical condition and the effectiveness of the ketogenic diet were followed-up every month for
1 year. Adverse events and the reasons for discontinuing the diet were recorded. Results: Fifty-three
patients (27 males and 26 females) were enrolled. At the end of the study, 21 patients remained on
the diet, 14 of whom were followed-up for 1 year. Among the 53 patients, 22.6% had a more than
50% reduction in seizure frequency, and 16.9% became seizure-free.
Conclusions: After a 1-year follow-up, the use of a medium-chain triglyceride ketogenic diet for patients
with drug-resistant epilepsy was found to be a safe and effective therapy, and may be considered to
bean alternative for patients with difficult-to-control seizures in children as well as young adults.
- Full text:P020170206407408662080.pdf
