Sex differences in large artery atherosclerotic stroke, a Korean study
- Author:
Cindy W Yoon
;
Hee-Kwon Park
;
Joung-Ho Rha
- Publication Type:Journal Article
- MeSH:
Stroke
- From:Neurology Asia
2016;21(4):311-316
- CountryMalaysia
- Language:English
-
Abstract:
Background & Objective: Sex differences in cerebral atherosclerosis and subsequent stroke have
not been thoroughly investigated and conflicting data exist. The aim of this study was to investigate
sex differences in the risk factors and distribution of large artery atherosclerotic stroke in a Korean
population. Methods: We included consecutive acute ischemic stroke patients with symptomatic
extracranial atherosclerosis (ECAS) or intracranial atherosclerosis (ICAS) based on brain and vascular
imaging who presented at our hospital between January 2011 and December 2015. We then compared
risk factor profiles and the proportion of symptomatic ECAS and ICAS between men and women.
Results: Eight hundred and forty four patients were enrolled during the study period. The proportion
of ECAS in men was notably higher than in women (19.4% in men vs. 9.3% in women; p < 0.001).
A multiple regression analysis showed that male gender was a factor favoring ECAS (vs. ICAS, odds
ratio [OR], 3.554; 95% confidence interval [CI], 2.175-5.808; p < 0.001). Age (OR, 1.051; 95% CI,
1.031-1.072; p = 0.001) and hyperlipidemia (OR, 2.330; 95% CI, 1.538-3.529; p < 0.001) were also
factors favoring ECAS. However, after stratification by sex, the association was only significant in men.
Conclusions: There is a sex difference in the distribution of atherosclerotic stroke. Sex may be an
effect modifier of the association between atherosclerotic risk factors and atherosclerotic distribution.
- Full text:P020170206392928510862.pdf
