Comorbid schizophrenia and Parkinson’s disease: a case series and brief review
- Author:
Jayoung Oh
;
Guangxun Shen
;
Guangxian Nan
;
Jong-Min Kim
;
Ki-Young Jung
;
Beomseok Jeon
- Publication Type:Journal Article
- From:Neurology Asia
2017;22(2):139-142
- CountryMalaysia
- Language:English
-
Abstract:
Traditionally, schizophrenia is considered to be a result of dopaminergic hyperactivity while
dopaminergic deficiency underlies Parkinson’s disease (PD). This opposing pathophysiology makes
comorbid schizophrenia and PD seemingly impossible; however, they do coexist rarely in clinical
practice. We present four patients with paranoid schizophrenia diagnosed in their youth who developed
parkinsonian symptoms on a stable regimen of quetiapine or clozapine after several years. The diagnosis
of comorbid schizophrenia and PD was made mainly according to clinical observation. In addition,
dopamine transporter (DAT) imaging with 18F-FP-CIT PET was done in two patients, which showed
normal DAT density. It is believed that dopaminergic dysfunction in distinct dopaminergic pathways
may explain the coexistence of these two disorders
- Full text:W020170710335715105597.pdf
