HLA-B*1502 and carbamazepine induced StevensJohnson syndrome/toxic epidermal necrolysis in Indonesia
- Author:
Herlyani Khosama
;
Astri Budikayanti
;
Amy Hui Ping Khor
;
Kheng Seang Lim
;
Ching-Ching Ng
;
Indra G Mansyur
;
Alida Harahap
;
Teguh AR Ranakusuma
;
Chong Tin Tan
- Publication Type:Journal Article
- Keywords:
Carbamazepine induced Steven-Johnson syndrome/toxic epidermal necrolysis;
hypersensitivity;
HLA-B*1502;
Indonesia
- From:Neurology Asia
2017;22(2):113-116
- CountryMalaysia
- Language:English
-
Abstract:
Background & Objective: Association between HLA-B*1502 and carbamazepine-induced StevenJohnson
syndrome/toxic epidermal necrolysis (CBZ-SJS/TEN) was reported in many Southeast Asian
populations but not in Indonesian. The purpose of this study was to evaluate the association between
HLA-B*1502 andCBZ-SJS/TEN in an Indonesian population. Methods: Patients with history of
CBZ-SJS/TEN are recruited as cases and those who tolerated CBZ as controls. HLA-B typing was
performed. Results: We recruited 14 cases with CBZ-SJS/TEN and 53 controls. Positive HLA-B*1502
was found in 8 (57.1%) cases and 14 (26.4%) controls (OR 3.7, 95% CI 1.09-12.61, p=0.035).
Conclusion: HLA-B*1502 is associated with CBZ-SJS/TEN patients in Indonesian.
- Full text:W020170710326365570522.pdf
