The Effect of 4-hydroxybenzaldehyde on the γ-aminobutyric Acid Type A Receptor
- Author:
Amelia Jane Lloyd
;
Abdul Aziz Mohamed Yusoff
;
Zamzuri Idris
;
Jafri Malin Abdullah
- Publication Type:Journal Article
- Keywords:
α1β2γ2 GABAA receptor, electrophysiology, Xenopus oocytes, bamboo shoot, GABAergic agents
- From:Malaysian Journal of Medical Sciences
2017;24(2):94-99
- CountryMalaysia
- Language:English
-
Abstract:
in the mammalian cortex and hippocampus. It is expressed heterologously in the
Xenopus laevis oocyte as a α1β2γ2S/L subtype for application as an in vitro model for the screening
of compounds that modulate receptor activities. In fact, 4-hydroxybenzaldehyde (4-HB) has
been identified as one of the major components in Dendrocalamus asper bamboo shoots in our
previous study, and the current study showed that at 101.7 μM, 4-HB significantly reduced the
GABA-induced chloride current of GABAA receptors expressed on Xenopus oocytes, indicating a
possible GABAergic antagonistic effect at high concentrations.
- Full text:P020170509552162593242.pdf
