Drosophila melanogaster: Deciphering Alzheimer's Disease
- Author:
Florence Hui Ping Tan
;
Ghows Azzam
- Publication Type:Journal Article
- Keywords:
Alzheimer, Drosophila, model organism
- From:Malaysian Journal of Medical Sciences
2017;24(2):6-20
- CountryMalaysia
- Language:English
-
Abstract:
Alzheimer's disease (AD) is the most widespread neurodegenerative disorder worldwide.
Its pathogenesis involves two hallmarks: aggregation of amyloid beta (Aβ) and occurrence of
neurofibrillary tangles (NFTs). The mechanism behind the disease is still unknown. This has
prompted the use of animal models to mirror the disease. The fruit fly, Drosophila melanogaster
has garnered considerable attention as an organism to recapitulate human disorders. With
the ability to monopolise a multitude of traditional and novel genetic tools, Drosophila is ideal
for studying not only cellular aspects but also physiological and behavioural traits of human
neurodegenerative diseases. Here, we discuss the use of the Drosophila model in understanding
AD pathology and the insights gained in discovering drug therapies for AD.
- Full text:P020170505389884151881.pdf
