A study of MTRR 66A>G gene polymorphism in patients with autism from northern Iran
- Author:
Samereh Ajabi
;
Farhad Mashayekhi
;
Elham Bidabadi
- Publication Type:Journal Article
- Keywords:
Autism;
methionine synthase reductase;
A66G polymorphism;
folate
- MeSH:
Autistic Disorder
- From:Neurology Asia
2017;22(1):58-64
- CountryMalaysia
- Language:English
-
Abstract:
Autism is a neurodevelopmental disorders that manifests before 3 years of age, more common in boys.
Whereas causes of autism remain uncertain, it is influenced by genetic and environmental factors. Recent
studies have shown that the genes involved in the folate metabolism pathway may play an important
role in autism. Methionine synthase reductase (MTRR) is a key enzyme that plays an important role
in the homocysteine/folate metabolism and has been shown to be implicated in neurological disorders
including autism. In this study, 356 subjects were studied, which consists of 142 autistic children and
214 nonautistic control. Genomic DNA was extracted from blood samples. Genotype of MTRR 66A>G
gene was performed using polymerase chain reaction-allele specific PCR (AS-PCR). The genotype
frequencies of AA, AG and GG in the children with autism were 9.9%, 76.0% and 14.1%, respectively
and in control group were 13.1%, 86.0% and 0.9%, respectively. The allele frequencies of A, G in
the children with autism were 48.0%, 52.0%, respectively and in control group were 56.0%, 44.0%,
respectively. Statistical analysis showed that there is a significant correlation in the genotype between
two groups (OR=20, 95% CI=4.1 to 98, P<0.001). It is concluded that MTRR A66G polymorphism
is associated with autism in a population in northern Iran. More studies with larger number should
be done to confirm this result.
- Full text:P020170413330341964429.pdf
