Hypometabolism based on a cutoff point on the mini-mental state examination in Parkinson’s disease
- Author:
Eun Joo Chung
;
Yong Hee Han
;
Chi WoongMun
;
Sang Kyun Bae
;
Seok Mo Lee
;
Hae Woong Jeong MD, Sang Jin Kim
- Publication Type:Journal Article
- Keywords:
Hypometabolism
- MeSH:
Parkinson Disease
- From:Neurology Asia
2016;21(3):247-253
- CountryMalaysia
- Language:English
-
Abstract:
Objective: The aim of the present study was to evaluate cortical hypometabolism of the F-18-
fluorodeoxyglucose positron emission tomography (FDG-PET) based on a diagnostic cutoff point of
the mini-mental state examination (MMSE) in de novo PD.Methods: We recruited 24 PD patients and
15 healthy controls to analyze FDG-PET. We divided the patients into two groups by the diagnostic
cutoff point of MMSE for diagnosing dementia, with scores of>25 vs. < 25. FDG-PET was processed
using statistical parametric mapping (SPM) 8 running on Matlab 11. Results: Patients with a MMSE <
25 presented lower score in time orientation, serial sevens, language and pentagon copying of MMSE
compared to patients with a MMSE >25. Compared to healthy controls, patients with a MMSE> 25
and < 25 showed a fronto-temporo-parietal hypometabolism, which was more extended in patients
with a MMSE < 25. Difference in cortical hypometabolism between patients with a MMSE >25 and
< 25 was found in the right inferior parietal lobule.
Conclusions: In the comparison by cutoff point of MMSE (25/24), hypometabolism in the right
inferior parietal lobule suggests that the posterior cortical deficit is the main region ofde novo PD
with cognitive impairment. Hypometabolism of right inferior parietal lobule is related to the damage
of cerebral networkin de novo PD.
- Full text:P020161014317561673183.pdf
