The Effect of Preventive, Therapeutic and Protective Exercises on Hippocampal Memory Mediators in Stressed Rats
- Author:
Maryam Radahmadi
;
Nasrin Hosseini
;
Hojjatallah Alaei
;
Muhammad Reza Sharifi
- Publication Type:Journal Article
- Keywords:
Stress;
Exercise;
Corticosterone;
Interleukin-1ßeta;
Brain-Derived Neurotrophic Factor;
Glucose
- From:Malaysian Journal of Medical Sciences
2016;23(5):29-37
- CountryMalaysia
- Language:English
-
Abstract:
Background: Exercise plays a significant role in learning and memory. The present study
focuses on the hippocampal corticosterone (CORT), interleukin-1 beta(IL-1β), glucose, and brainderived
neurotrophic factor (BDNF) levels in preventive, therapeutic, and protective exercises in
stressful conditions.
Methods: Forty male rats were randomly divided into four groups: the control group and
the preventive, therapeutic, and protective exercise groups. The treadmill running was applied at
a speed of 20-21m/min and a chronic stress of 6 hours/day for 21 days. Subsequently, the variables
were measured in the hippocampus.
Results: The findings revealed that the hippocampal CORT levels in the preventive
exercise group had a significant enhancement compared to the control group. In the protective
and particularly the therapeutic exercise groups, the hippocampal CORT levels declined.
Furthermore, the hippocampal BDNF levels in the preventive and the therapeutic exercise groups
indicated significantly decreased and increased, respectively, in comparison with the control
group. In the preventive exercise group, however, the hippocampal glucose level turned out to be
substantially higher than that in the control group.
Conclusion: It appears that the therapeutic exercise group had the best exercise protocols
for improving the hippocampal memory mediators in the stress conditions. By contrast, the
preventive exercise group could not improve these mediators that had been altered by stress. It
is suggested that exercise time, compared to stress, can be considered as a crucial factor in the
responsiveness of memory mediators.
- Full text:P020161009636936296482.pdf
