Protective Effects of Defatted Dabai Peel Extracts in Hypercholesterolemic Rabbits Based on Histopathological Methods
- Author:
Hock Eng Khoo
;
Azrina Azlan
;
Amin Ismail
;
Sadek Hassan Al-Sheraji
- Publication Type:Journal Article
- Keywords:
Dabai;
Extract;
Histopathology;
Hypercholesterolemic;
Organ
- MeSH:
Anthocyanins
- From:Malaysian Journal of Medicine and Health Sciences
2015;11(2):59-68
- CountryMalaysia
- Language:English
-
Abstract:
Defatted dabai peel contains a high amount of anthocyanin. Anthocyanins are known to prevent several
types of disease, including cardiovascular-related complications. This study aimed to describe the
effects of different doses of defatted dabai peel extract by histopathological analyses on lesions in the
liver, kidney, heart and aorta. Histopathology methods were applied to determine the protective effects
of defatted dabai peel extracts against hypercholesterolemia-induced oxidative damages to animal
organs. Haematoxylin and eosin staining was applied for histopathology examination for liver, kidney,
heart and aorta. Data showed that a high dose of defatted dabai extract (3000 mg per day) applied to
hypercholesterolemic rabbits for eight weeks had mild protective effect, especially reducing the severity
of hepatic fibrosis and steatosis of the renal medulla. The high dose of extract supplementation also
reduced inflammation of aorta and formation of atherosclerosis plaque in the cell wall of right ventricle
of the heart. The high dose of defatted dabai peel extract could be a protective agent against oxidative
stress.
- Full text:P020151209546646886327.pdf
