Role of cerebrovascular risk factors in dementia
- Author:
Shaun Hiu
;
Marissa Ong
;
Nagaendran Kandiah
- Publication Type:Review
- MeSH:
Dementia;
Cerebrovascular Disorders
- From:Neurology Asia
2016;21(2):103-111
- CountryMalaysia
- Language:English
-
Abstract:
With the rapid increase in the prevalence of dementia worldwide there has been significant research
into modifiable risk factors for dementia. In this regard cerebrovascular diseases (CVD) represent
a potential therapeutic target in the fight against the epidemic of dementia. Both large vessel CVD
and small vessel disease in the form of chronic lacunes, white matter hyperintensity, microbleeds,
and perivascular spaces have been strongly associated with the risk of developing dementia. These
CVD factors may initiate or accelerate the amyloid and tau cascades resulting in greater rates of
neurodegeneration and dementia. Understanding the precise mechanisms for the interaction between
CVD and neurodegeneration will allow development of potential interventional targets. These CVD
risk factors may be of particular relevance to the Asian population where a high burden of small vessel
CVD has been demonstrated in Asian patients with dementia
- Full text:P020160714320497399325.pdf
