Evaluation of Endothelial Cell Adhesion Molecules and Anti-C1q Antibody in Discriminating between Active and Non-Active Systemic Lupus Erythematosus
- Author:
Hasni Mahayidin
;
Nurul Khaiza Yahya
;
Wan Syamimee Wan Ghazali
;
Asmahan Mohd Ismail
;
Wan Zuraida Wan Ab Hamid
- Publication Type:Journal Article
- Keywords:
cell adhesion molecules;
intercellular adhesion molecule-1 (ICAM-1);
vascular cell adhesion molecule-1 (VCAM-1);
anti-C1q antibody;
systemic lupus erythematosus
- From:Malaysian Journal of Medical Sciences
2016;23(3):22-31
- CountryMalaysia
- Language:English
-
Abstract:
Background
: Detecting the active state of systemic lupus erythematosus (SLE) is important
but challenging. This study aimed to determine the diagnostic accuracy of serum endothelial cell
adhesion molecules (ICAM-1 and VCAM-1) and anti-C1q antibody in discriminating between active
and non-active SLE.
Methods:
Using SELENA-SLE disease activity index (SLEDAI), 95 SLE patients (45 active
and 50 non-active) were assessed. A score above five was considered indicative of active SLE. The
blood samples were tested for serum ICAM-1, VCAM-1 and anti-C1q antibody using enzyme-linked
immunosorbent assay (ELISA).
Results:
The levels of serum VCAM-1 and anti-C1q antibody were significantly higher in active
SLE patients. Both VCAM-1 and anti-C1q were able to discriminate between active and non-active
SLE (
p
-value < 0.001 and 0.005, respectively). From the receiver operating characteristic curves
(ROCs) constructed, the optimal cut-off values for VCAM-1 and anti-C1q antibody in discriminating
between active and non-active SLE were 30.5 ng/mL (69.0% sensitivity, 60.0% specificity, PPV 58.5%,
NPV 66.7%) and 7.86 U/mL (75.6% sensitivity, 80% specificity, PPV 77.3%, NPV 78.4%), respectively.
However, serum ICAM-1 level was unable to discriminate between the two groups (
p
-value = 0.193).
Conclusion:
Anti-C1q antibody demonstrated the best diagnostic accuracy in discriminating
between active and non-active SLE patients
- Full text:P020160518629605399522.pdf
